Dynhalosperm® has been developed in response to the needs of our clients to evaluate the kinetic aspects of DNA fragmentation.
The interest in the study of the kinetics of fragmentation is growing, because the use of ex vivo sperm samples may produce iatrogenic damage, which differs significantly between individuals. It has been shown that sperm DNA damage is present from the time of ejaculation and increases over time. The longevity of DNA is different among different patients. Those who have high baseline ratios of fragmentation or whose fragmentation increases faster than average over time, need to be identified to avoid additional iatrogenic damage.
Dynhalosperm® allows medical professionals to add more information to the clinical diagnosis at the time of selecting the reproductive technique best suited to each couple. For example, for a patient with a high increase in the degree of DNA fragmentation in the first few minutes after ejaculating, it would be advisable to direct him to a technique that ensures short periods of in vitro manipulation and rapid fertilisation of the oocyte.
In this way, Dynhalosperm® is useful for selecting the optimal timing of the assisted reproduction cycle, evaluating the quality of the sperm sample and providing answers to cases of idiopathic infertility or repeated miscarriages, among other causes.
Discrimination of ejaculates with different DNA longevity.
Blue line: patient with low fragmentation levels after ejaculation, but with a high rate of sperm DNA damage. Low longevity
Green line: patient with high fragmentation levels, but with a low rate of sperm DNA damage. High longevity
In the first case, the insemination or the sperm selection for the assisted reproduction technique must be carried out immediately to avoid additional iatrogenic damage. The incidence of this damage in the second patient is not as intense, and the handling of the sample and technique used can be adapted as a result.