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Oxidative Stress and Male Infertility in the Region of Peja in Republic of Kosovo

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Afrim Zeqiraj*1 , Sheqibe Beadini2 , Nexhbedin Beadini2 , Zafer Gashi1 , Sadi Bexheti3 , Shkelzen Elezaj4 , Sanije Berisha5 and Agim Shabani6

  1. Department of Biochemistry, FAMA Colleague, Republic of Kosovo, Kosovo
  2. Department of Biology, University of Tetovo, Republic of Macedonia, Macedonia
  3. Faculty of Medicine, University of Tetovo, Republic of Macedonia, Macedonia
  4. Clinic of Urology, Regional Hospital of Peja, Republic of Kosovo, Kosovo
  5. Department of Biochemistry, University clinical center, Tetovo, Republic of Macedonia, Macedonia
  6. Department of Chemistry, University of Tetovo, Republic of Macedonia, Macedonia



Oxidative stress is a pathology that is found in 40-50% of all infertile males. Oxidative stress occurs when the production of peroxides exceeds the antioxidant protection of the organism resulting in damage to the sperm. Oxidative stress is known as one of the most important causes of male infertility. Purpose of the work, it is to determine the degree of male infertility in infertile males caused by oxidative stress. The study was conducted in Regjion of Peja, in the Republic of Kosovo.


Sampling was conducted for a period of 2017/2018, a total of 77 samples, 47 samples for analysis and 30 samples for control were collected. Oxidative stress analysis in the ejaculate was performed at the Biolab-Zafi Laboratory in Peja, Republic of Kosovo. Oxidative stress analysis is performed with the aid of the Oxisperm/Halotech, S.L. Madrid, Spain. The importance of the presentation is at (p<0.05).


The results show significant levels (p<0.004) of oxidative stress between the working group and the control group.


In our paper we have found high significance of oxidative stress in infertile male ejaculation compared to the control group of patients taken in the study. For determining the oxidative stress regensi Oxisperm/Halotech is selected because of ease of use, both in terms of practice as well as cost. An assessment of the levels of oxidative stress in men’s ejaculation should become part of routine work in clinical andrology laboratories to assist clinicians in determining infertility status and in establishing optimal medical treatment. We acknowledge that this study is a new technique in our country and requires more general studies and should be repeated by other authors and compared with other methods for evaluating sperm DNA damage. It is also necessary to make a link between oxidative stress and fragmented DNA in the sperm.