Halotech's solutions arise from our understanding of the need to study and better understand the male factor. We are aware of the reality of the laboratory and the clinic. All of the information that can be provided to the patient is precious, and our kits aim to improve the treatment prognosis for each of them.
An early, comprehensive semen analysis can identify potential problems to avoid embarking upon costly and repeated Assisted Reproductive Technology (ART). Conventional semen analysis only studies spermatozoa concentration, motility and morphology. It is an incomplete study, as it omits analysis of one of the most important parameters, the integrity of the DNA molecule. In addition, knowing the levels of oxidative stress and the quality of the spermatozoon’s membrane guarantees a better diagnosis for subsequent fertility treatment.
15% of men who are considered infertile present normal semen analysis results:
DNA fragmentation + excessive oxidative stress + and the lack of vitality in the spermatozoon = fertility rate and embryo development failures
DNA fragmentation, excessive oxidative stress, and the lack of vitality in the spermatozoon correlate directly with a low fertility rate and with failures in embryonic development.
This translates into an increase in the number of cycles needed to achieve pregnancy through IUI (Intrauterine Insemination), IVF (In Vitro Fertilization) or ICSI (Intracytoplasmic Sperm Injection), deterioration of embryo quality and repeated miscarriages. Halotech diagnostic solutions avoid this, providing more information to the medical professional.
The next step is to treat the patient suffering from these problems. Treatment with antioxidants may significantly reduce levels of DNA fragmentation. The response to treatment varies as a function of the causes that can cause said damage: if this results from toxic factors or high temperatures that activate sperm caspases and endonucleases, it is difficult to modify levels of DNA fragmentation in sperm. Spermatozoa that come from the first portion of the ejaculate have lower levels of DNA fragmentation. On the other hand, repeated ejaculation or the use of spermatozoa originating in the testicle can achieve similar results depending on the type of patient. The effectiveness of these strategies must be evaluated by your medical professional in each case, which varies among patients.
Therefore, our kits maintain the philosophy of helping the medical professional enhance treatment, advising and providing quality and innovation. We help treat sperm DNA damage, which is a multifactorial process. Tobacco use, obesity, tight clothing, ingestion of certain drugs, fever, advanced age, chemotherapy or radiotherapy, are environmental factors that can produce an increase in sperm DNA fragmentation levels. Some natural factors like improper maturation or oxidative stress translate into failures during the production of spermatozoa in the testicle, which result in the same response.
Halotech solutions aim to improve the prospects of our patients at a reasonable cost, with an innovative technique applicable to any laboratory thanks to its simplicity. The results confirm our research: DNA fragmentation is important when it comes to selecting a couple’s assisted reproductive technology. It has been demonstrated that it is related to the probability of full-term pregnancy during IUI cycles. Levels above 30% reduce the likelihood of success from 19% to 1.5%. Knowing this data, we can select alternative techniques to IUI. In IVF treatments, fragmentation levels below 25% lead to a live birth rate of 33%. With fragmentation levels greater than 50%, this rate falls to 13%.
Niveles superiores al 30% disminuyen la probabilidad de éxito del 19% al 1,5%. Conociendo este dato podemos elegir técnicas alternativas al IUI. En tratamientos FIV, niveles de fragmentación inferiores al 25% conllevan una tasa de nacimientos vivos del 33%. Con niveles de fragmentación superiores al 50%, esta tasa cae hasta el 13%.